Deciphering imprints of impaired memory B-cell maturation in germinal centers of three patients with common variable immunodeficiency
Common variable immunodeficiency (CVID), characterized by recurrent infections, low serum class-switched immunoglobulin isotypes, and poor antigen-specific antibody responses, comprises a heterogeneous patient population in terms of clinical presentation and underlying etiology.The diagnosis is regularly associated with a severe decrease of germina